diff --git a/caps/tests/unit/xpcshell.toml b/caps/tests/unit/xpcshell.toml
index a04efc4be5ea..20265348b709 100644
--- a/caps/tests/unit/xpcshell.toml
+++ b/caps/tests/unit/xpcshell.toml
@@ -9,7 +9,6 @@ head = ""
 
 ["test_precursor_principal.js"]
 firefox-appdir = "browser"
-skip-if = ["os == 'android'"]
 
 ["test_site_origin.js"]
 
diff --git a/chrome/test/unit_ipc/xpcshell.toml b/chrome/test/unit_ipc/xpcshell.toml
index 2beb2c849d3a..f618f6f50d39 100644
--- a/chrome/test/unit_ipc/xpcshell.toml
+++ b/chrome/test/unit_ipc/xpcshell.toml
@@ -1,6 +1,5 @@
 [DEFAULT]
 head = ""
-skip-if = ["os == 'android'"]
 support-files = [
   "!/chrome/test/unit/data/**",
   "!/chrome/test/unit/test_resolve_uris.js",
@@ -8,3 +7,4 @@ support-files = [
 ]
 
 ["test_resolve_uris_ipc.js"]
+# skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug && !socketprocess_networking"] # Bug TBD
diff --git a/docshell/test/unit/xpcshell.toml b/docshell/test/unit/xpcshell.toml
index abc775f1aedf..1b5f78ddebcd 100644
--- a/docshell/test/unit/xpcshell.toml
+++ b/docshell/test/unit/xpcshell.toml
@@ -11,20 +11,18 @@ support-files = [
 ["test_URIFixup_check_host.js"]
 
 ["test_URIFixup_external_protocol_fallback.js"]
-skip-if = ["os == 'android'"]
+skip-if = ["os == 'android' && android_version == '24' && processor == 'x86_64'"]
 
 ["test_URIFixup_forced.js"]
 # Disabled for 1563343 -- URI fixup should be done at the app level in GV.
-skip-if = ["os == 'android'"]
 
 ["test_URIFixup_info.js"]
-skip-if = ["os == 'android'"]
+skip-if = ["os == 'android' && android_version == '24' && processor == 'x86_64'"]
 
 ["test_URIFixup_search.js"]
-skip-if = ["os == 'android'"]
+skip-if = ["os == 'android' && android_version == '24' && processor == 'x86_64'"]
 
 ["test_allowJavascript.js"]
-skip-if = ["os == 'android'"]
 support-files = [
   "AllowJavascriptChild.sys.mjs",
   "AllowJavascriptParent.sys.mjs",
@@ -35,8 +33,7 @@ support-files = [
 ["test_bug442584.js"]
 
 ["test_pb_notification.js"]
-# Bug 751575: unrelated JS changes cause timeouts on random platforms
-skip-if = ["true"]
+skip-if = ["true"] # Bug 751575: unrelated JS changes cause timeouts on random platforms
 
 ["test_privacy_transition.js"]
 
diff --git a/docshell/test/unit_ipc/xpcshell.toml b/docshell/test/unit_ipc/xpcshell.toml
index 9ddc971a2482..3683455b0751 100644
--- a/docshell/test/unit_ipc/xpcshell.toml
+++ b/docshell/test/unit_ipc/xpcshell.toml
@@ -1,8 +1,5 @@
 [DEFAULT]
 head = ""
-skip-if = ["os == 'android'"]
 
 ["test_pb_notification_ipc.js"]
-# Bug 751575: Perma-fails with: command timed out: 1200 seconds without output
-skip-if = ["true"]
-
+skip-if = ["true"] # Bug 751575: Perma-fails with: command timed out: 1200 seconds without output
diff --git a/dom/base/test/unit/xpcshell.toml b/dom/base/test/unit/xpcshell.toml
index 5895c96e9516..3c8752be4446 100644
--- a/dom/base/test/unit/xpcshell.toml
+++ b/dom/base/test/unit/xpcshell.toml
@@ -27,10 +27,7 @@ support-files = [
 
 ["test_blockParsing.js"]
 prefs = ["dom.security.https_first=false"]
-skip-if = [
-  "debug", # We fail an assertion if we block parsing on a self-closing element
-  "os == 'android'",
-]
+run-if = ["!debug"] # We fail an assertion if we block parsing on a self-closing element
 
 ["test_bug553888.js"]
 
@@ -49,10 +46,6 @@ prefs = ["network.xhr.block_sync_system_requests=false"] # Bug 721336
 
 ["test_error_codes.js"]
 run-sequentially = "Hardcoded 4444 port."
-skip-if = [
-  "os == 'mac'", # Bug 1018414: hardcoded localhost doesn't work properly on some OS X installs
-  "os == 'linux' && os_version == '18.04' && processor == 'x86_64' && ccov", # Bug 1933914
-]
 
 ["test_generate_xpath.js"]
 head = "head_xml.js"
diff --git a/dom/base/test/unit_ipc/xpcshell.toml b/dom/base/test/unit_ipc/xpcshell.toml
index 8e1b5159418c..3d17a074105e 100644
--- a/dom/base/test/unit_ipc/xpcshell.toml
+++ b/dom/base/test/unit_ipc/xpcshell.toml
@@ -1,9 +1,5 @@
 [DEFAULT]
 head = ""
-skip-if = [
-  "os == 'android'",
-  "socketprocess_networking",
-]
 support-files = [
   "!/dom/base/test/unit/test_bug553888.js",
   "!/dom/base/test/unit/test_xhr_document.js",
diff --git a/dom/cache/test/xpcshell/xpcshell.toml b/dom/cache/test/xpcshell/xpcshell.toml
index ecf2646f05ea..4d9d4ba0cde6 100644
--- a/dom/cache/test/xpcshell/xpcshell.toml
+++ b/dom/cache/test/xpcshell/xpcshell.toml
@@ -6,10 +6,9 @@ support-files = [
   "schema_15_profile.zip",
   "schema_25_profile.zip",
 ]
-# dummy test entry to generate profile zip files
 
 ["make_profile.js"]
-skip-if = ["true"]
+run-if = ["false"] # dummy test entry to generate profile zip files
 
 ["test_bug1425146.js"]
 
diff --git a/dom/console/tests/xpcshell/xpcshell.toml b/dom/console/tests/xpcshell/xpcshell.toml
index c683a8db91aa..880e95d5ad25 100644
--- a/dom/console/tests/xpcshell/xpcshell.toml
+++ b/dom/console/tests/xpcshell/xpcshell.toml
@@ -7,14 +7,14 @@ support-files = ""
 ["test_console_shouldLog.js"]
 
 ["test_failing_console_listener.js"]
-skip-if = ["tsan"]
+skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && tsan"]
 
 ["test_formatting.js"]
 
 ["test_reportForServiceWorkerScope.js"]
 
 ["test_worker.js"]
-skip-if = ["os == 'android'"] # Uses ChromeWorker.
 support-files = [
   "worker.mjs",
 ]
+run-if = ["os != 'android'"] # Uses ChromeWorker.
diff --git a/dom/file/tests/xpcshell.toml b/dom/file/tests/xpcshell.toml
index 712d9965d61c..37270635c63f 100644
--- a/dom/file/tests/xpcshell.toml
+++ b/dom/file/tests/xpcshell.toml
@@ -5,4 +5,3 @@
 ["test_createFile.js"]
 
 ["test_ipc_messagemanager_blob.js"]
-skip-if = ["os == 'android'"]
diff --git a/dom/fs/test/common/xpcshell.toml b/dom/fs/test/common/xpcshell.toml
index 9f086b65fea3..59a6e05d108e 100644
--- a/dom/fs/test/common/xpcshell.toml
+++ b/dom/fs/test/common/xpcshell.toml
@@ -7,4 +7,3 @@ support-files = [
 ]
 
 ["dummy.js"]
-skip-if = ["true"]
diff --git a/dom/indexedDB/test/unit/xpcshell-parent-process.toml b/dom/indexedDB/test/unit/xpcshell-parent-process.toml
index 4eac50e82bf8..9be44ffbfb66 100644
--- a/dom/indexedDB/test/unit/xpcshell-parent-process.toml
+++ b/dom/indexedDB/test/unit/xpcshell-parent-process.toml
@@ -30,7 +30,7 @@ support-files = [
 ["include:xpcshell-shared.toml"]
 
 ["make_URLSearchParams.js"]
-skip-if = ["true"] # Only used for recreating URLSearchParams_profile.zip
+run-if = ["false"] # Only used for recreating URLSearchParams_profile.zip
 
 ["test_URLSearchParams.js"]
 
@@ -44,7 +44,7 @@ skip-if = ["true"] # Only used for recreating URLSearchParams_profile.zip
 
 ["test_clear_object_store_with_indexes.js"]
 requesttimeoutfactor = 2
-skip-if = ["tsan"]
+skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && tsan && !fission && socketprocess_networking"] # Bug TBD
 
 ["test_connection_idle_maintenance.js"]
 
@@ -61,7 +61,6 @@ skip-if = ["tsan"]
 ["test_file_copy_failure.js"]
 
 ["test_globalObjects_ipc.js"]
-skip-if = ["os == 'android'"]
 
 ["test_idbSubdirUpgrade.js"]
 
@@ -111,17 +110,11 @@ skip-if = ["true"]
 
 ["test_temporary_storage.js"]
 skip-if = [
-  # bug 951017: intermittent failure on Android x86 emulator
-  "os == 'android' && processor == 'x86'",
-  # bug 1942783
-  "inc_origin_init",
+  "inc_origin_init", # bug 1942783
 ]
 
 ["test_transaction_durability.js"]
 run-sequentially = "very high failure rate in parallel"
-skip-if = [
-  "os == 'linux' && os_version == '18.04' && processor == 'x86_64' && ccov", # Bug 1933914
-]
 
 ["test_unexpectedDirectory.js"]
 
diff --git a/dom/indexedDB/test/unit/xpcshell-shared.toml b/dom/indexedDB/test/unit/xpcshell-shared.toml
index f967236a9e47..92a82de26bf9 100644
--- a/dom/indexedDB/test/unit/xpcshell-shared.toml
+++ b/dom/indexedDB/test/unit/xpcshell-shared.toml
@@ -3,6 +3,7 @@
 ["test_abort_deleted_index.js"]
 
 ["test_abort_deleted_objectStore.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug && socketprocess_networking"] # Bug TBD
 
 ["test_add_put.js"]
 
@@ -17,7 +18,6 @@
 ["test_blocked_order.js"]
 
 ["test_clear.js"]
-skip-if = ["os == 'win' && debug"]  # Bug 1785080
 
 ["test_complex_keyPaths.js"]
 
@@ -28,13 +28,13 @@ skip-if = ["os == 'win' && debug"]  # Bug 1785080
 ["test_create_index_with_integer_keys.js"]
 
 ["test_create_locale_aware_index.js"]
-skip-if = ["os == 'android'"] # bug 864843
 
 ["test_create_objectStore.js"]
 
 ["test_cursor_cycle.js"]
 
 ["test_cursor_mutation.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD
 
 ["test_cursor_update_updates_indexes.js"]
 
@@ -43,21 +43,28 @@ skip-if = ["os == 'android'"] # bug 864843
 ["test_deleteDatabase.js"]
 
 ["test_deleteDatabase_interactions.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD (secondary)
 
 ["test_deleteDatabase_onblocked.js"]
 
 ["test_deleteDatabase_onblocked_duringVersionChange.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD (secondary)
 
 ["test_event_source.js"]
 
 ["test_getAll.js"]
 
 ["test_globalObjects_other.js"]
-skip-if = ["os == 'android'"] # bug 1079278
+skip-if = [
+  "os == 'android'", # bug 1079278
+  "os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug && socketprocess_networking", # Bug TBD (secondary)
+]
 
 ["test_globalObjects_xpc.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug && socketprocess_networking"] # Bug TBD (secondary)
 
 ["test_global_data.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug && socketprocess_networking"] # Bug TBD (secondary)
 
 ["test_index_empty_keyPath.js"]
 
@@ -82,16 +89,10 @@ skip-if = ["os == 'android'"] # bug 1079278
 ["test_key_requirements.js"]
 
 ["test_keys.js"]
-skip-if = [
-  "tsan", # Uncatched OOM crashes
-  "asan",
-] # bug 1796753
 
 ["test_locale_aware_index_getAll.js"]
-skip-if = ["os == 'android'"] # bug 864843
 
 ["test_locale_aware_index_getAllObjects.js"]
-skip-if = ["os == 'android'"] # bug 864843
 
 ["test_multientry.js"]
 
@@ -100,6 +101,7 @@ skip-if = ["os == 'android'"] # bug 864843
 ["test_objectCursors.js"]
 
 ["test_objectStore_getAllKeys.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD (secondary)
 
 ["test_objectStore_inline_autoincrement_key_added_on_put.js"]
 
@@ -124,15 +126,18 @@ skip-if = ["os == 'android'"] # bug 864843
 ["test_overlapping_transactions.js"]
 
 ["test_put_get_values.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD (secondary)
 
 ["test_put_get_values_autoIncrement.js"]
 skip-if = ["verify && debug && os == 'win'"]
 
 ["test_readonly_transactions.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD (secondary)
 
 ["test_remove_index.js"]
 
 ["test_remove_objectStore.js"]
+skip-if = ["os == 'mac' && os_version == '10.15' && processor == 'x86_64' && debug"] # Bug TBD (secondary)
 
 ["test_rename_index.js"]
 
diff --git a/dom/ipc/tests/xpcshell.toml b/dom/ipc/tests/xpcshell.toml
index 1ddd8328a1c1..e7cd9a2552e3 100644
--- a/dom/ipc/tests/xpcshell.toml
+++ b/dom/ipc/tests/xpcshell.toml
@@ -1,18 +1,14 @@
 [DEFAULT]
 
 ["test_blob_sliced_from_child_process.js"]
-skip-if = ["os == 'android' && processor == 'x86_64'"]
 
 ["test_blob_sliced_from_parent_process.js"]
-skip-if = ["os == 'android' && processor == 'x86_64'"]
 
 ["test_bug1086684.js"]
-skip-if = ["os == 'android' && processor == 'x86_64'"]
 
 ["test_child_docshell.js"]
-skip-if = ["os == 'android' && processor == 'x86_64'"]
 
 ["test_headless_content_process.js"]
 
 ["test_sharedMap.js"]
-skip-if = ["os == 'android' && processor == 'x86_64'"]
+skip-if = ["os == 'android' && android_version == '24' && processor == 'x86_64' && debug"]
diff --git a/dom/localstorage/test/unit/xpcshell.toml b/dom/localstorage/test/unit/xpcshell.toml
index af1d2b0b4183..f31b44eb5750 100644
--- a/dom/localstorage/test/unit/xpcshell.toml
+++ b/dom/localstorage/test/unit/xpcshell.toml
@@ -19,10 +19,10 @@ support-files = [
 ]
 
 ["make_migration_emptyValue.js"]
-skip-if = ["true"] # Only used for recreating migration_emptyValue_profile.zip
+run-if = ["false"] # Only used for recreating migration_emptyValue_profile.zip
 
 ["make_somedata.js"]
-skip-if = ["true"] # Only used for recreating somedata_profile.zip
+run-if = ["false"] # Only used for recreating somedata_profile.zip
 
 ["test_archive.js"]
 
@@ -104,7 +104,6 @@ support-files = ["migration_emptyValue_profile.zip",]
 ["test_slowStorageInitialization.js"]
 
 ["test_snapshotting.js"]
-skip-if = ["tsan"] # Unreasonably slow, bug 1612707
 requesttimeoutfactor = 4
 
 ["test_stringLength.js"]
diff --git a/dom/messagechannel/tests/unit/xpcshell.toml b/dom/messagechannel/tests/unit/xpcshell.toml
index ea6d7d18629c..0495a3f83959 100644
--- a/dom/messagechannel/tests/unit/xpcshell.toml
+++ b/dom/messagechannel/tests/unit/xpcshell.toml
@@ -1,6 +1,6 @@
 [DEFAULT]
 head =  ""
-skip-if = ["os == 'android'"]
 support-files = ["chromeWorker_messageChannel.js"]
+skip-if = ["os == 'android' && android_version == '24' && processor == 'x86_64'"]
 
 ["test_messageChannel.js"]
diff --git a/dom/notification/test/unit/xpcshell.toml b/dom/notification/test/unit/xpcshell.toml
index 54ae8a7adfd0..1e2da50aab44 100644
--- a/dom/notification/test/unit/xpcshell.toml
+++ b/dom/notification/test/unit/xpcshell.toml
@@ -1,6 +1,5 @@
 [DEFAULT]
 head = "head_notificationdb.js"
-skip-if = ["os == 'android'"]
 
 ["test_notificationdb.js"]
 
diff --git a/dom/privateattribution/tests/xpcshell/xpcshell.toml b/dom/privateattribution/tests/xpcshell/xpcshell.toml
index 7a1151fcee3f..81acf07f6429 100644
--- a/dom/privateattribution/tests/xpcshell/xpcshell.toml
+++ b/dom/privateattribution/tests/xpcshell/xpcshell.toml
@@ -1,4 +1,4 @@
 [DEFAULT]
+run-if = ["os != 'android'"] # PPA is not supported on Android
 
 ["test_ppa.js"]
-skip-if = ["os == 'android'"] # PPA is not supported on Android
diff --git a/dom/push/test/xpcshell/xpcshell.toml b/dom/push/test/xpcshell/xpcshell.toml
index a830c9473fd8..9ff91ecf8a33 100644
--- a/dom/push/test/xpcshell/xpcshell.toml
+++ b/dom/push/test/xpcshell/xpcshell.toml
@@ -1,8 +1,7 @@
 [DEFAULT]
 head = "head.js"
-# Push notifications and alarms are currently disabled on Android.
-skip-if = ["os == 'android'"]
 support-files = ["broadcast_handler.sys.mjs"]
+skip-if = ["os == 'android'"] # Push notifications and alarms are currently disabled on Android.
 
 ["test_broadcast_success.js"]
 
@@ -11,10 +10,6 @@ support-files = ["broadcast_handler.sys.mjs"]
 # silently disabled, so now we explicitly call out the platforms not known
 # to have node installed.
 run-sequentially = "This will delete all existing push subscriptions."
-skip-if = [
-  "os == 'android'",
-  "os == 'linux' && os_version == '18.04' && processor == 'x86_64' && ccov", # Bug 1933914
-]
 
 ["test_clear_forgetAboutSite.js"]
 
@@ -47,9 +42,6 @@ skip-if = ["true"]
 
 ["test_permissions.js"]
 run-sequentially = "This will delete all existing push subscriptions."
-skip-if = [
-  "os == 'linux' && os_version == '18.04' && processor == 'x86_64' && ccov", # Bug 1933914
-]
 
 ["test_quota_exceeded.js"]
 
@@ -106,8 +98,7 @@ skip-if = [
 ["test_unregister_invalid_json.js"]
 run-sequentially = "very high failure rate in parallel"
 skip-if = [
-  "os == 'win'", # Bug 1627379
-  "os == 'linux' && os_version == '18.04' && processor == 'x86_64' && ccov", # Bug 1933914
+  "os == 'linux' && os_version == '18.04' && processor == 'x86_64' && tsan", # Bug 1933914
 ]
 
 ["test_unregister_not_found.js"]
@@ -115,4 +106,3 @@ skip-if = [
 ["test_unregister_success.js"]
 
 ["test_updateRecordNoEncryptionKeys_ws.js"]
-skip-if = ["os == 'linux'"] # Bug 1265233
diff --git a/dom/quota/test/xpcshell/caching/xpcshell.toml b/dom/quota/test/xpcshell/caching/xpcshell.toml
index 305ca8fc12a4..3fe013c06816 100644
--- a/dom/quota/test/xpcshell/caching/xpcshell.toml
+++ b/dom/quota/test/xpcshell/caching/xpcshell.toml
@@ -7,7 +7,7 @@ support-files = [
 ]
 
 ["make_unsetLastAccessTime.js"]
-skip-if = ["true"] # Only used for recreating unsetLastAccessTime_profile.zip
+run-if = ["false"] # Only used for recreating unsetLastAccessTime_profile.zip
 
 ["test_groupMismatch.js"]
 
diff --git a/dom/quota/test/xpcshell/telemetry/xpcshell.toml b/dom/quota/test/xpcshell/telemetry/xpcshell.toml
index 93b22540c026..d0ca7b5fdbbe 100644
--- a/dom/quota/test/xpcshell/telemetry/xpcshell.toml
+++ b/dom/quota/test/xpcshell/telemetry/xpcshell.toml
@@ -16,15 +16,13 @@ support-files = [
 
 ["test_dom_quota_try.js"]
 skip-if = [
-  "os == 'android'",
-  "appname == 'thunderbird'",
-  # bug 1942789
+  "appname == 'thunderbird'", # bug 1942789
   "inc_origin_init",
+  "os == 'android' && android_version == '24' && processor == 'x86_64'",
 ]
 
 ["test_qm_first_initialization_attempt.js"]
 skip-if = [
-  "appname == 'thunderbird'",
-  # bug 1942790
+  "appname == 'thunderbird'", # bug 1942790
   "inc_origin_init",
 ]
diff --git a/dom/quota/test/xpcshell/xpcshell.toml b/dom/quota/test/xpcshell/xpcshell.toml
index d191c691796a..da551137cb4a 100644
--- a/dom/quota/test/xpcshell/xpcshell.toml
+++ b/dom/quota/test/xpcshell/xpcshell.toml
@@ -30,16 +30,16 @@ support-files = [
 ]
 
 ["make_getCachedUsageForPrincipal.js"]
-skip-if = ["true"] # Only used for recreating getCachedUsageForPrincipal_profile.zip
+run-if = ["false"] # Only used for recreating getCachedUsageForPrincipal_profile.zip
 
 ["make_getUsageForPrincipal.js"]
-skip-if = ["true"] # Only used for recreating getUsageForPrincipal_profile.zip
+run-if = ["false"] # Only used for recreating getCachedUsageForPrincipal_profile.zip
 
 ["make_unknownFiles.js"]
-skip-if = ["true"] # Only used for recreating unknownFiles_profile.zip
+run-if = ["false"] # Only used for recreating unknownFiles_profile.zip
 
 ["make_unsetLastAccessTime.js"]
-skip-if = ["true"] # Only used for recreating unsetLastAccessTime_profile.zip
+run-if = ["false"] # Only used for recreating unsetLastAccessTime_profile.zip
 
 ["test_allowListFiles.js"]
 
@@ -74,12 +74,11 @@ skip-if = ["true"] # Only used for recreating unsetLastAccessTime_profile.zip
 ["test_groupInitializationStarted.js"]
 
 ["test_groupMismatch.js"]
-skip-if = ["true"] # The group is now always empty, so metadata can't differ anymore.
+run-if = ["false"] # The group is now always empty, so metadata can't differ anymore.
 
 ["test_idle_maintenance.js"]
 
 ["test_initTemporaryStorage.js"]
-skip-if = ["condprof"] # frequent perma fail, then goes away.
 
 ["test_initializeAllTemporaryOrigins.js"]
 # The test cannot function correctly with incremental origin initialization
@@ -108,14 +107,14 @@ skip-if = ["inc_origin_init"]
 
 ["test_originEndsWithDot.js"]
 
+["test_originInitializationStarted.js"]
+
 ["test_originMismatch.js"]
 # bug 1942793
 skip-if = ["inc_origin_init"]
 
 ["test_originWithCaret.js"]
 
-["test_originInitializationStarted.js"]
-
 ["test_orpahnedQuotaObject.js"]
 
 ["test_persist.js"]
@@ -132,8 +131,6 @@ skip-if = ["inc_origin_init"]
 
 ["test_removeLocalStorage.js"]
 
-["test_simpledb.js"]
-
 ["test_shutdownDuringAllTemporaryOriginsInitialization.js"]
 # The test cannot function correctly with incremental origin initialization
 # enabled  because incremental origin initialization automatically triggers
@@ -148,14 +145,12 @@ skip-if = ["inc_origin_init"]
 # initialization is complete.
 skip-if = ["inc_origin_init"]
 
+["test_simpledb.js"]
+
 ["test_specialOrigins.js"]
 
 ["test_storagePressure.js"]
-skip-if = [
-  "condprof",
-  # bug 1942794
-  "inc_origin_init",
-]
+skip-if = ["inc_origin_init"]
 
 ["test_tempMetadataCleanup.js"]
 
diff --git a/dom/security/test/unit/xpcshell.toml b/dom/security/test/unit/xpcshell.toml
index ed12b23f31ac..dc4a834c68f9 100644
--- a/dom/security/test/unit/xpcshell.toml
+++ b/dom/security/test/unit/xpcshell.toml
@@ -9,10 +9,10 @@ head = ""
 
 ["test_deserialization_format_before_100.js"]
 
+["test_get_trusted_types_compliant_string.js"]
+
 ["test_https_only_https_first_default_port.js"]
 
 ["test_https_only_https_first_prefs.js"]
 
 ["test_isOriginPotentiallyTrustworthy.js"]
-
-["test_get_trusted_types_compliant_string.js"]
diff --git a/dom/streams/test/xpcshell/xpcshell.toml b/dom/streams/test/xpcshell/xpcshell.toml
index c6fd879f2f61..d9f35df50d68 100644
--- a/dom/streams/test/xpcshell/xpcshell.toml
+++ b/dom/streams/test/xpcshell/xpcshell.toml
@@ -1,6 +1,5 @@
 [DEFAULT]
 head = "head.js"
-skip-if = ["os == 'android'"]
 support-files = ""
 
 ["bug-1387503-1.js"]
@@ -15,10 +14,6 @@ prefs = ["security.allow_parent_unrestricted_js_loads=true"]
 ["fetch.js"]
 
 ["large-pipeto.js"]
-skip-if = [
-  "os == 'win'",
-  "tsan", # Causes claim expired errors; see Bug 1770170.
-]
 run-sequentially = "very high failure rate in parallel"
 
 ["proper-realm-cancel.js"]
diff --git a/dom/tests/unit/xpcshell.toml b/dom/tests/unit/xpcshell.toml
index 85c9186f106b..357c234ca4f0 100644
--- a/dom/tests/unit/xpcshell.toml
+++ b/dom/tests/unit/xpcshell.toml
@@ -13,10 +13,6 @@
 ["test_geolocation_position_unavailable.js"]
 
 ["test_geolocation_position_unavailable_wrap.js"]
-skip-if = [
-  "os == 'mac'",
-  "os == 'android'",
-]
 
 ["test_geolocation_provider.js"]
 
@@ -24,22 +20,16 @@ skip-if = [
 
 ["test_geolocation_reset_accuracy.js"]
 skip-if = [
-  "os == 'win' && os_version == '11.2009' && processor == 'x86_64' && opt && msix", # Bug 1822179
   "os == 'win' && os_version == '11.26100' && processor == 'x86_64' && opt && msix", # Bug 1822179
 ]
 
 ["test_geolocation_reset_accuracy_wrap.js"]
 skip-if = [
-  "os == 'mac'",
-  "os == 'android'",
+  "os == 'win' && os_version == '11.26100' && processor == 'x86_64' && opt && msix", # Bug 1822179
 ]
 
 ["test_geolocation_timeout.js"]
 
 ["test_geolocation_timeout_wrap.js"]
-skip-if = [
-  "os == 'mac'",
-  "os == 'android'",
-]
 
 ["test_xhr_init.js"]
diff --git a/dom/webtransport/test/xpcshell/xpcshell.toml b/dom/webtransport/test/xpcshell/xpcshell.toml
index 0695d452af38..a2583fe29c49 100644
--- a/dom/webtransport/test/xpcshell/xpcshell.toml
+++ b/dom/webtransport/test/xpcshell/xpcshell.toml
@@ -3,27 +3,25 @@
 # file, You can obtain one at http://mozilla.org/MPL/2.0/.
 
 [DEFAULT]
+run-if = ["!socketprocess_networking"]
 # XXX figure out why android doesn't get MOZHTTP3_PORT
 skip-if = [
-  "os == 'android'",
-  "socketprocess_networking",
-  "os == 'win' && msix", # https://bugzilla.mozilla.org/show_bug.cgi?id=1807925
+  "os == 'android' && android_version == '24' && processor == 'x86_64'",
+  "os == 'win' && os_version == '11.26100' && processor == 'x86_64' && msix", # https://bugzilla.mozilla.org/show_bug.cgi?id=1807925
 ]
 
 ["test_close.js"]
 
 ["test_simple_conn.js"]
-skip-if = [
-  "!fission && debug",
-  "verify && tsan",
-  "verify && debug",
-]
 run-sequentially = "http3server"
+skip-if = [
+  "os == 'win' && os_version == '10.2009' && processor == 'x86_64'", # Bug TBD
+  "os == 'win' && os_version == '11.26100' && processor == 'x86'", # Bug TBD
+]
 
 ["test_simple_stream.js"]
-skip-if = [
-  "!fission && debug",
-  "verify && tsan",
-  "verify && debug",
-]
 run-sequentially = "http3server"
+skip-if = [
+  "os == 'win' && os_version == '10.2009' && processor == 'x86_64'", # Bug TBD
+  "os == 'win' && os_version == '11.26100' && processor == 'x86'", # Bug TBD
+]
diff --git a/dom/workers/test/xpcshell/xpcshell.toml b/dom/workers/test/xpcshell/xpcshell.toml
index 61b1eef0c25b..069e669a8019 100644
--- a/dom/workers/test/xpcshell/xpcshell.toml
+++ b/dom/workers/test/xpcshell/xpcshell.toml
@@ -1,5 +1,4 @@
 [DEFAULT]
-skip-if = ["os == 'android'"]
 support-files = [
   "data/worker.js",
   "data/worker_fileReader.js",
@@ -8,6 +7,7 @@ support-files = [
   "data/base_uri_module.mjs",
   "data/base_uri_module2.mjs",
 ]
+skip-if = ["os == 'android' && android_version == '24' && processor == 'x86_64'"]
 
 ["test_ext_redirects_sw_scripts.js"]
 # The following firefox-appdir make sure that ExtensionTestUtils.loadExtension
@@ -30,7 +30,6 @@ firefox-appdir = "browser"
 firefox-appdir = "browser"
 # Disable plugin loading to make it rr able to record and replay this test.
 prefs = ["plugin.disable=true"]
-skip-if = ["socketprocess_networking"] # Bug 1759035
 
 
 ["test_workers.js"]