diff --git a/devtools/shared/async-storage.js b/devtools/shared/async-storage.js
index b858ed449373..65a10f3425e6 100644
--- a/devtools/shared/async-storage.js
+++ b/devtools/shared/async-storage.js
@@ -51,6 +51,8 @@ const DBVERSION = 1;
 const STORENAME = "keyvaluepairs";
 var db = null;
 
+loader.lazyRequireGetter(this, "indexedDB", "devtools/shared/indexed-db");
+
 function withStore(type, onsuccess, onerror) {
   if (db) {
     const transaction = db.transaction(STORENAME, type);
diff --git a/devtools/shared/indexed-db.js b/devtools/shared/indexed-db.js
index aba8f6833f28..a4ea57c76f5c 100644
--- a/devtools/shared/indexed-db.js
+++ b/devtools/shared/indexed-db.js
@@ -9,24 +9,28 @@
  * a principal dedicated to DevTools.
  */
 
-const PSEUDOURI = "indexeddb://fx-devtools";
-const principaluri = Services.io.newURI(PSEUDOURI);
-const principal = Services.scriptSecurityManager.createContentPrincipal(
-  principaluri,
-  {}
-);
+// When running in jest, we can't use Cu.Sandbox and only expose the native indexedDB object
+if (globalThis.indexedDB) {
+  module.exports = globalThis.indexedDB;
+} else {
+  const PSEUDOURI = "indexeddb://fx-devtools";
+  const principaluri = Services.io.newURI(PSEUDOURI);
+  const principal = Services.scriptSecurityManager.createContentPrincipal(
+    principaluri,
+    {}
+  );
 
-/**
- * Create the DevTools dedicated DB, by relying on the real indexedDB object passed as a
- * parameter here.
- *
- * @param {IDBFactory} indexedDB
- *        Real indexedDB object.
- * @return {Object} Wrapper object that implements IDBFactory methods, but for a devtools
- *         specific principal.
- */
-exports.createDevToolsIndexedDB = function(indexedDB) {
-  return Object.freeze({
+  // indexedDB is only exposed to document globals.
+  // We are retrieving an instance from a Sandbox, which has to be loaded
+  // from the system principal in order to avoid having wrappers around
+  // all indexed DB objects.
+  const systemPrincipal = Services.scriptSecurityManager.getSystemPrincipal();
+  const sandbox = Cu.Sandbox(systemPrincipal, {
+    wantGlobalProperties: ["indexedDB"],
+  });
+  const { indexedDB } = sandbox;
+
+  module.exports = Object.freeze({
     /**
      * Only the standard version of indexedDB.open is supported.
      */
@@ -37,12 +41,14 @@ exports.createDevToolsIndexedDB = function(indexedDB) {
       }
       return indexedDB.openForPrincipal(principal, name, options);
     },
+
     /**
      * Only the standard version of indexedDB.deleteDatabase is supported.
      */
     deleteDatabase(name) {
       return indexedDB.deleteForPrincipal(principal, name);
     },
+
     cmp: indexedDB.cmp.bind(indexedDB),
   });
-};
+}
diff --git a/devtools/shared/loader/base-loader.js b/devtools/shared/loader/base-loader.js
index 62a6d697611c..3b4adb8b58ee 100644
--- a/devtools/shared/loader/base-loader.js
+++ b/devtools/shared/loader/base-loader.js
@@ -132,7 +132,6 @@ function Sandbox(options) {
       "FileReader",
       "FormData",
       "Headers",
-      "indexedDB",
       "InspectorUtils",
       "Node",
       "TextDecoder",
diff --git a/devtools/shared/loader/builtin-modules.js b/devtools/shared/loader/builtin-modules.js
index 4b5d53ffe52f..4c862cbe729f 100644
--- a/devtools/shared/loader/builtin-modules.js
+++ b/devtools/shared/loader/builtin-modules.js
@@ -271,8 +271,3 @@ lazyGlobal("setInterval", () => {
 lazyGlobal("WebSocket", () => {
   return Services.appShell.hiddenDOMWindow.WebSocket;
 });
-lazyGlobal("indexedDB", () => {
-  return require("devtools/shared/indexed-db").createDevToolsIndexedDB(
-    indexedDB
-  );
-});